Home › Compound Library › Tissue Repair & Recovery › Larazotide Acetate (AT-1001)
Tissue Repair & Recovery Research Moderate Evidence

Larazotide Acetate (AT-1001)

Tight junction regulator studied for celiac disease, leaky gut, and intestinal permeability research. Competitive inhibitor of zonulin — the protein that opens intestinal tight junctions. Phase 3 trials conducted for celiac.

tight junctionleaky gutzonulinceliacintestinal permeabilitygut barrierAT-1001
Half-life
Topically active in gut lumen; minimal systemic absorption by design
SKUs Available
1
Evidence Level
Moderate Evidence
Mechanism of Action

Peptide antagonist of zonulin (haptoglobin-2 precursor) signaling. Competes with zonulin at tight junction receptor sites, preventing tight junction opening. Preserves intestinal barrier integrity under gluten or toxin challenge. Reduces systemic immune activation from gut permeability.

Published Research Ranges & Study Context

Studies have administered: 0.5–2mg three times daily oral in celiac phase 2/3 trials

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Phase 2b (Fasano group): 1mg TID significantly reduced gluten-induced symptoms vs placebo. Phase 3 primary endpoint missed but patient-reported outcomes improved. Leaky gut research applications broad and ongoing.

Moderate Evidence Phase 1/2 human trials available
Side Effects Observed in Research

Well-tolerated in all trials; GI events similar to placebo; minimal systemic absorption limits systemic AEs

Available Configurations (SKU Reference)
LAR1
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

Want a Complete Research Monograph?

Our AI can generate a 2,000+ word deep-dive on Larazotide Acetate (AT-1001) — including full clinical trial summaries, pharmacokinetics, and research frontiers.

Generate Deep Dive in Research Chat
Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.