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Longevity & Mitochondrial Research Moderate Evidence

Nicotinamide Riboside (NR)

NAD+ precursor vitamin B3 analogue. First orally bioavailable NAD+ booster with human clinical trial data. Studied for cardiovascular health, neuroprotection, metabolic function, and healthy aging.

NAD+NRvitamin B3longevitymitochondriacardiovascularsirtuin
Half-life
Plasma NR brief; measured as sustained NAD+ elevation lasting hours-days
SKUs Available
2
Evidence Level
Moderate Evidence
Mechanism of Action

Converted to NMN then NAD+ via NRK1/NRK2 kinases. Unique entry point into NAD+ biosynthesis salvage pathway. Activates SIRT1, SIRT3 mitochondrial sirtuin, PARPs. Shown to improve mitochondrial function in preclinical models.

Published Research Ranges & Study Context

Studies have administered: 250–1000mg/day oral; 300mg and 1000mg most studied doses in human trials

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Trammell (2016): NR raises blood NAD+ 40–90% in humans. Martens (2018): 1000mg/day for 6 weeks improved systolic blood pressure and arterial stiffness in older adults. Multiple safety trials through 2024 demonstrate tolerability.

Moderate Evidence Phase 1/2 human trials available
Side Effects Observed in Research

Generally well-tolerated; mild nausea occasionally; comparatively less flushing than nicotinic acid

Available Configurations (SKU Reference)
NR250 NR500
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.