Home Compound Library Growth Hormone Axis Sermorelin
Growth Hormone Axis Research High Evidence

Sermorelin

First 29 amino acids of endogenous GHRH. FDA-approved (now withdrawn) GHRH analogue; most studied GH secretagogue with the longest clinical history.

ghrhgrowth hormoneigf-1pituitaryanti-agingsermorelin
Half-life
11–12 minutes; stimulates prolonged GH pulse
SKUs Available
2
Evidence Level
High Evidence
Mechanism of Action

Binds pituitary GHRH receptors to stimulate endogenous GH production. Preserves hypothalamic-pituitary feedback loop — prevents suppression of endogenous GH production.

Published Research Ranges & Study Context

Studies have administered: 0.2–0.3mg/kg at bedtime in clinical studies; 0.5–2mg/day studied

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Extensive clinical trial history (FDA-reviewed). Studies demonstrate increased GH pulse amplitude and IGF-1 elevation with preservation of pulsatile physiology.

High Evidence Multiple large human RCTs available
Side Effects Observed in Research

Generally well-tolerated; injection site redness, facial flushing in some studies

Available Configurations (SKU Reference)
SMO5 SMO10
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.