Scientific Glossary

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GHRPs are synthetic peptides that act on the ghrelin receptor (GHSR-1a) to stimulate GH release. Unlike GHRH, GHRPs do not require GHRH activity — they activate a complementary and synergistic pathway. When GHRH and GHRP are combined, GH pulses are dramatically amplified (2-10x in some studies) compared to either alone. This synergy is the scientific basis for GHRH+GHRP combination research protocols. Examples: ipamorelin, GHRP-6, hexarelin.