Scientific Glossary

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RCT design features that reduce bias: randomization (eliminates selection bias), blinding (reduces performance and detection bias), placebo/active control comparison (establishes true treatment effect), pre-specified endpoints (prevents cherry-picking outcomes). Double-blind RCTs (neither participants nor researchers know allocation) are the strongest single-study design. The GLP-1 agonist trial programs (STEP, SUSTAIN, SURMOUNT, SELECT) are landmark RCTs with tens of thousands of participants and years of follow-up. Most research peptides lack this level of evidence.