Scientific Glossary

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Steady state is reached after approximately 4-5 half-lives of regular dosing. At steady state, plasma concentrations oscillate predictably between a minimum (trough) and maximum (peak) without continuing to accumulate. For a compound with a 7-day half-life (like semaglutide), steady state requires roughly 5-6 weeks of weekly dosing. Most clinical trial efficacy data is measured at or near steady state.