Home › Compound Library › Specialty › GHK-Cu Complex (Copper Tripeptide)
Specialty Research Moderate Evidence

GHK-Cu Complex (Copper Tripeptide)

Extended research compound entry for GHK-Cu copper peptide complex including systemic administration studies beyond topical use. Studied for lung fibrosis (anti-fibrotic), wound contraction, nerve regeneration, and anti-tumor effects.

coppertripeptideGHKwound healinganti-fibrotichair growthsystemicgenomic
Half-life
Topical: local; systemic: ~40 minutes plasma for tripeptide backbone
SKUs Available
1
Evidence Level
Moderate Evidence
Mechanism of Action

GHK-Cu (Gly-His-Lys + Cu2+) coordinates copper for tissue repair signaling. Activates 32 tissue remodeling genes, suppresses 21 inflammation genes per genomic studies (Pickart). Anti-fibrotic: reduces TGF-β1 mediated collagen overproduction. Angiogenic: promotes VEGF and FGF-7 in wound beds. Neuro: promotes nerve sprouting.

Published Research Ranges & Study Context

Studies have administered: Topical: 0.1–5%; Systemic research: 10–100mcg/kg SC in wound and lung models; human systemic very limited

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Pickart (30+ year research career): comprehensive genomic characterization. Wound healing: FDA-cleared wound dressings. Lung fibrosis animal models: reversal of established fibrosis. Hair loss: human scalp studies show follicle stimulation. Anti-tumor: growth inhibition in multiple cancer lines.

Moderate Evidence Phase 1/2 human trials available
Side Effects Observed in Research

Topical: excellent safety; systemic: copper toxicity concern at supraphysiological doses; systemic protocols require copper monitoring

Available Configurations (SKU Reference)
GHK-CU2
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

Want a Complete Research Monograph?

Our AI can generate a 2,000+ word deep-dive on GHK-Cu Complex (Copper Tripeptide) — including full clinical trial summaries, pharmacokinetics, and research frontiers.

Generate Deep Dive in Research Chat
Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.