Home › Compound Library › Cognitive & Mood › Dihexa
Cognitive & Mood Research Emerging

Dihexa

Hepatocyte growth factor receptor (HGF/c-Met) agonist peptide. Described in preclinical studies as millions of times more potent than BDNF for synaptogenesis. Studied for Alzheimer disease, cognitive enhancement, and neurological repair.

HGFsynaptogenesiscognitiveAlzheimernootropicc-Metneuroplasticity
Half-life
Not well-characterized; highly lipophilic, likely CNS accumulation
SKUs Available
1
Evidence Level
Emerging
Mechanism of Action

Binds HGF receptor system indirectly — angiotensin IV analogue that prevents angiotensinase degradation of HGF, increasing endogenous HGF/c-Met signaling. Potent synaptogenesis promoter: increases dendritic spine density and new synapse formation. Robust cognitive enhancement in animal models.

Published Research Ranges & Study Context

Studies have administered: Animal: 1mg/kg oral or intranasal; human dosing not established; no clinical trials published

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

McCoy (2013, Rockefeller): cognitive enhancement in aged and Alzheimer model rats — task performance fully restored. Synaptogenesis: direct imaging confirmed new synapse formation. One of strongest cognitive enhancement signals in published preclinical literature. Human trials absent.

Emerging Early-stage research — limited human data
Side Effects Observed in Research

Human safety profile entirely unknown; theoretical concern of uncontrolled synaptogenesis; lipophilic accumulation risk; no clinical trial data

Available Configurations (SKU Reference)
DHX5
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

Want a Complete Research Monograph?

Our AI can generate a 2,000+ word deep-dive on Dihexa — including full clinical trial summaries, pharmacokinetics, and research frontiers.

Generate Deep Dive in Research Chat
Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.