Flavonoid polyphenol (found in strawberries, apples) studied as a senolytic — selectively clears senescent "zombie" cells. Mayo Clinic clinical trials ongoing for frailty and age-related conditions.
2–4 hours; rapid metabolism; intermittent high-dose "burst" protocols common in research
SKUs
1
Evidence
Preliminary
Fisetin is a naturally occurring flavonoid found in strawberries, apples, persimmons, and other fruits and vegetables. It has generated significant research interest as a potential senolytic agent — a compound that selectively clears aging cells (senescent cells) from the body. It is also studied for anti-inflammatory and neuroprotective properties. Human trials are underway but early-stage.
Senolytic Research
Fisetin is among the compounds studied by aging researchers for its ability to selectively trigger cell death in senescent cells — cells that have stopped dividing, resist dying, and secrete inflammatory signals. Animal studies from the Mayo Clinic and other institutions showed that fisetin eliminated senescent cells and extended healthspan in aged mice.
Neuroprotective Research
Cell and animal studies have examined fisetin for protection against neurodegeneration. It has shown effects on memory and learning in animal models of Alzheimer's disease and normal aging, reducing amyloid pathology and inflammation in some studies.
Anti-Inflammatory Research
As a flavonoid, fisetin inhibits multiple inflammatory pathways including NF-kB and reduces production of inflammatory cytokines. These effects have been documented in cell culture and animal studies.
Human Trials
Early-phase human trials (including from the Mayo Clinic's SToMP-AD trial) have been conducted to evaluate safety and feasibility of fisetin dosing in older adults and Alzheimer's patients. These trials focus on safety and biomarker changes rather than clinical outcomes.
Animal studies show senescent cell clearance and healthspan extension in aged mice.
Neuroprotective effects and improved cognitive performance in multiple rodent Alzheimer's models.
Anti-inflammatory effects documented in cell culture and animal research.
Early human trials confirm it is well-tolerated at studied doses.
Clinical efficacy in humans has not yet been demonstrated in completed trials.
Fisetin has notable bioavailability challenges — it is rapidly metabolized and has inconsistent absorption, making it difficult to achieve the concentrations in human tissue that produce effects in cell and animal studies. Human efficacy data do not yet exist in completed trials. The senolytic effects seen in animals have not been confirmed in humans. It is widely available as a supplement, but supplement-grade products may vary significantly in quality and actual fisetin content.
As cells age, some of them enter a state called senescence — they stop dividing normally but refuse to die. These zombie-like cells sit in tissues producing inflammatory signals that gradually damage surrounding healthy cells. Researchers believe the accumulation of senescent cells is a significant driver of aging-related decline. Fisetin appears to selectively activate programmed cell death pathways in these senescent cells while largely leaving healthy cells alone — a property called senolytic activity. It also acts as an antioxidant and reduces inflammatory signaling more broadly. In animal studies, periodic high-dose fisetin treatment appears to reduce the senescent cell burden and improve various markers of aging.
Fisetin is generally considered safe in human studies conducted to date, with no significant adverse effects reported at doses up to 20mg/kg in early trials. It is available as an over-the-counter supplement. Oral bioavailability is low and variable. There are no known serious drug interactions, though it may interact with medications that are substrates of certain liver enzymes. It is not FDA-approved as a drug for any indication.
Preliminary
Most evidence comes from preclinical studies and case reports. Human data is limited and more research is needed.
Published Research Ranges
20mg/kg intermittent (burst dosing) per Mayo protocol extrapolations; human trials 100–1000mg/day being evaluated
Research Context Only: These are ranges reported in published scientific studies for educational reference. They are not dosing recommendations. This is not medical advice. Always consult a qualified healthcare professional.
Sources listed here are from the platform research library. All links open the original publication. No citations are generated by AI.
Fisetin Is a Senotherapeutic That Extends Health and Lifespan
Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action
Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress
Research Education Only: This profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions.
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