Home › Compound Library › Longevity & Mitochondrial › Fisetin
Longevity & Mitochondrial Research Preliminary

Fisetin

Flavonoid polyphenol (found in strawberries, apples) studied as a senolytic — selectively clears senescent "zombie" cells. Mayo Clinic clinical trials ongoing for frailty and age-related conditions.

senolyticsenescenceflavonoidlongevityinflammationagingzombie cells
Half-life
~2–4 hours; rapid metabolism; intermittent high-dose "burst" protocols common in research
SKUs Available
1
Evidence Level
Preliminary
Mechanism of Action

Senolytic activity: selectively induces apoptosis in senescent cells via inhibition of PI3K/AKT/mTOR survival pathway. Anti-inflammatory: inhibits NF-κB signaling. Antioxidant: direct ROS scavenging and Nrf2 activation. SIRT1 activation reported in some models.

Published Research Ranges & Study Context

Studies have administered: 20mg/kg intermittent (burst dosing) per Mayo protocol extrapolations; human trials 100–1000mg/day being evaluated

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Yousefzadeh (2018) EBioMedicine: strongest senolytic activity among 10 flavonoids tested; extended lifespan in aged mice 10–15%. Reduced inflammatory markers in elderly humans in phase 1. Multiple Mayo Clinic trials ongoing 2024.

Preliminary Primarily preclinical + case reports
Side Effects Observed in Research

Well-tolerated in human studies to date; theoretical concern of eliminating some beneficial senescent cells

Available Configurations (SKU Reference)
FIS500
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

Want a Complete Research Monograph?

Our AI can generate a 2,000+ word deep-dive on Fisetin — including full clinical trial summaries, pharmacokinetics, and research frontiers.

Generate Deep Dive in Research Chat
Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.