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Longevity & Mitochondrial Research Moderate Evidence

Rapamycin (Sirolimus)

mTOR inhibitor — among the most studied longevity compounds. Extends lifespan in every model organism tested including mice. Human longevity trials ongoing (PEARL trial, Participatory Evaluation of Aging with Rapamycin). Immune-suppression drug repurposed for aging research.

mTORlongevityautophagylifespansenescenceimmune aginggeroscience
Half-life
~57–63 hours in healthy adults; allows once-weekly intermittent dosing in longevity protocols
SKUs Available
2
Evidence Level
Moderate Evidence
Mechanism of Action

Allosteric inhibitor of mTORC1 (mechanistic target of rapamycin complex 1) via FKBP12 binding. mTORC1 inhibition activates autophagy, reduces cellular senescence, improves proteostasis, and modulates immune aging. Intermittent dosing may preserve benefits while minimizing immune suppression.

Published Research Ranges & Study Context

Studies have administered: 1–6mg/week intermittent in longevity research context (off-label); higher doses in transplant medicine

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Harrison et al. (2009): first demonstration of lifespan extension in normal mice. Multiple replications. ITP (Interventional Testing Program): robust lifespan extension across multiple labs. Human data: improved vaccine response in older adults (Joan Mannick trial). PEARL trial ongoing.

Moderate Evidence Phase 1/2 human trials available
Side Effects Observed in Research

Mouth sores (stomatitis) dose-dependent; transient glucose elevation; lipid changes; immune suppression at therapeutic doses warrants monitoring

Available Configurations (SKU Reference)
RAP1 RAP5
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.