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Growth Hormone Axis Research Moderate Evidence

Hexarelin

Potent synthetic hexapeptide GH secretagogue — among the most potent GHS-R1a agonists. Studied for cardiac repair beyond GH axis effects via direct CD36 receptor activity. Orphan drug potential for growth hormone deficiency.

GHRPhexapeptideGH releasecardiacCD36secretagoguepotent
Half-life
~30–45 minutes; pulsatile dosing required to avoid desensitization
SKUs Available
2
Evidence Level
Moderate Evidence
Mechanism of Action

High-affinity GHS-R1a agonist with greater intrinsic efficacy than GHRP-2 or GHRP-6. Unique: direct cardioprotective mechanism via CD36 scavenger receptor activation independent of GH axis. Anti-apoptotic in cardiac myocytes. Some evidence of GH receptor desensitization with continuous use.

Published Research Ranges & Study Context

Studies have administered: 1–2mcg/kg per injection; 200mcg maximum typical dose in research; cycling recommended

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Most potent GH releaser in GHRP class. Cardiac: Dickson (2001) demonstrated cardioprotection in MI models independent of GH. IGF-1 elevation sustained. Desensitization well-documented — necessitates intermittent cycling.

Moderate Evidence Phase 1/2 human trials available
Side Effects Observed in Research

Greater cortisol, prolactin co-stimulation than ipamorelin; tachyphylaxis with continuous use; water retention; hyperprolactinemia risk with long-term use

Available Configurations (SKU Reference)
HEX2 HEX5
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.