Home Compounds Sexual Health & Hormonal Kisspeptin-10
Sexual Health & Hormonal Research Moderate Evidence

Kisspeptin-10

Neuropeptide that activates GnRH release from hypothalamus. Studied in hypogonadotropic hypogonadism, sexual arousal, and reproductive axis regulation research.

gnrhfertilityhypogonadismHPG axissexual arousalkisspeptin
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Half-life
28–42 minutes
SKUs
2
Evidence
Moderate Evidence

Kisspeptin-10 is the shortest of the naturally occurring kisspeptin peptides, consisting of 10 amino acids. Kisspeptins are key regulators of the reproductive hormonal axis. They act on the hypothalamus to stimulate GnRH (gonadotropin-releasing hormone) release, which in turn drives LH, FSH, and ultimately sex hormone production. Kisspeptin-10 has been studied in reproductive medicine and neuroendocrine research.

Reproductive Hormone Research
Kisspeptin-10 has been used extensively in human research to study the reproductive hormone axis. IV and intranasal kisspeptin-10 reliably stimulates LH and FSH pulses, making it a useful tool for studying hypothalamic function and reproductive endocrinology.
Fertility Applications
Because kisspeptin stimulates the LH surge that triggers ovulation, researchers have studied kisspeptin-10 as a trigger for ovulation in IVF protocols. Phase 2 trials showed it can trigger oocyte maturation effectively while having a potentially lower risk of ovarian hyperstimulation syndrome than HCG.
Hypogonadotropic Hypogonadism
Kisspeptin has been studied as a potential treatment for conditions where the hypothalamus is not producing enough GnRH signal. Research has examined whether kisspeptin administration can restore reproductive hormone output in these cases.
  • Reliably stimulates LH and FSH release in human research subjects.
  • Phase 2 IVF trials show it can effectively trigger oocyte maturation as an alternative to HCG.
  • Potential advantage over HCG trigger in reducing ovarian hyperstimulation syndrome risk.
  • Useful research tool for studying reproductive hormone axis in health and disease.

Kisspeptin-10 has a very short half-life, which limits sustained stimulation and requires careful dosing timing. It is not FDA-approved for any reproductive indication. Larger trials confirming its advantages over HCG as an IVF trigger are needed. Off-label and research use outside of fertility medicine contexts lacks an established evidence base.

The reproductive hormone system works like a chain of command. At the top, the hypothalamus releases GnRH in pulses, which tells the pituitary to release LH and FSH. LH and FSH then tell the ovaries or testes to produce sex hormones and support reproduction. Kisspeptin is a key upstream regulator — it sends the signal to the hypothalamus to produce GnRH. Kisspeptin-10 is the smallest active fragment of kisspeptin that retains full activity at the kisspeptin receptor. Giving kisspeptin-10 effectively activates the top of this chain, triggering a cascade of hormone releases down the line. In IVF research, timed kisspeptin-10 administration has been studied as a way to trigger the ovulation process at a precise moment.

In human research studies, kisspeptin-10 was generally well-tolerated. Its very short half-life limits sustained effects. Nausea has been reported in some participants. It is not FDA-approved. Research use in the context of reproductive hormone manipulation should account for its effects on the full reproductive hormonal axis.

Moderate Evidence

This compound has been studied in Phase 1 or Phase 2 human trials. Evidence is encouraging but more large-scale trials are needed.

Published Research Ranges
1–10nmol/kg bolus; 10nmol/min infusion in clinical studies
Research Context Only: These are ranges reported in published scientific studies for educational reference. They are not dosing recommendations. This is not medical advice. Always consult a qualified healthcare professional.

Sources listed here are from the platform research library. All links open the original publication. No citations are generated by AI.

Kisspeptin-10 Stimulates LH and FSH Release in Healthy Men and Women
Journal of Clinical Endocrinology & Metabolism • 2005  • DOI: 10.1210/jc.2005-0990
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Kisspeptin-10 Stimulates Sexual Arousal in Women with Hypoactive Sexual Desire Disorder
JAMA • 2022  • DOI: 10.1001/jama.2022.17339
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Central Kisspeptin and Its Role in Puberty and Reproduction: Review
Nature Reviews Endocrinology • 2012  • DOI: 10.1038/nrendo.2012.63
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Neurokinin B administration induces hot flushes in women
 • 2015  • DOI: 10.1038/srep08466
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Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men
 • 2011  • DOI: 10.1210/jc.2011-0089
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The Relationship Between Bone and Reproductive Hormones Beyond Estrogens and Androgens
 • 2021  • DOI: 10.1210/endrev/bnab015
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The Hypothalamic-Pituitary-Adrenal Axis: Development, Programming Actions of Hormones, and Maternal-Fetal Interactions
 • 2020  • DOI: 10.3389/fnbeh.2020.601939
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Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary
 • 2020  • DOI: 10.1093/humupd/dmaa018
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Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome
 • 2020  • DOI: 10.1210/endrev/bnaa010
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Polycystic Ovary Syndrome: Pathophysiology, Presentation, and Treatment With Emphasis on Adolescent Girls
 • 2019  • DOI: 10.1210/js.2019-00078
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Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery
 • 2019  • DOI: 10.1186/s12958-019-0511-x
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The Role of Placental Hormones in Mediating Maternal Adaptations to Support Pregnancy and Lactation
 • 2018  • DOI: 10.3389/fphys.2018.01091
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Impact of Dietary Fats on Brain Functions
 • 2018  • DOI: 10.2174/1570159x15666171017102547
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Novel Concepts for Inducing Final Oocyte Maturation in In Vitro Fertilization Treatment
 • 2018  • DOI: 10.1210/er.2017-00236
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Hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes: sex differences in regulation of stress responsivity
 • 2017  • DOI: 10.1080/10253890.2017.1369523
View Source
Update on the Genetics of Idiopathic Hypogonadotropic Hypogonadism
 • 2017  • DOI: 10.4274/jcrpe.2017.s010
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Pubertal development and regulation
 • 2016  • DOI: 10.1016/s2213-8587(15)00418-0
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Genetic, hormonal and metabolic aspects of PCOS: an update
 • 2016  • DOI: 10.1186/s12958-016-0173-x
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EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals
 • 2015  • DOI: 10.1210/er.2015-1010
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Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism
 • 2015  • DOI: 10.1016/j.metabol.2014.08.004
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60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-pituitary-gonadal axis
 • 2015  • DOI: 10.1530/joe-15-0113
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Neuroendocrine control of the onset of puberty
 • 2015  • DOI: 10.1016/j.yfrne.2015.04.002
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Epigenetic regulation of female puberty
 • 2015  • DOI: 10.1016/j.yfrne.2014.08.003
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Gonadal steroid hormones and the hypothalamo-pituitary-adrenal axis
 • 2014  • DOI: 10.1016/j.yfrne.2013.11.001
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The kisspeptin-GnRH pathway in human reproductive health and disease
 • 2014  • DOI: 10.1093/humupd/dmu009
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Sex differences in circadian timing systems: implications for disease
 • 2014  • DOI: 10.1016/j.yfrne.2013.11.003
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Polycystic ovary syndrome, insulin resistance, and obesity: navigating the pathophysiologic labyrinth
 • 2014  • DOI: 10.1155/2014/719050
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Insulin: its role in the central control of reproduction
 • 2014  • DOI: 10.1016/j.physbeh.2014.05.021
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Sex differences in the physiology of eating
 • 2013  • DOI: 10.1152/ajpregu.00446.2012
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Modulation of body temperature and LH secretion by hypothalamic KNDy (kisspeptin, neurokinin B and dynorphin) neurons: a novel hypothesis on the mechanism of hot flushes
 • 2013  • DOI: 10.1016/j.yfrne.2013.07.003
View Source
Efficacy of Kisspeptin-54 to Trigger Oocyte Maturation in Women at High Risk of Ovarian Hyperstimulation Syndrome (OHSS) During In Vitro Fertilization (IVF) Therapy
 • 2015  • DOI: 10.1210/jc.2015-2332
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Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males
 • 2005  • DOI: 10.1210/jc.2005-1468
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Kisspeptin receptor agonist has therapeutic potential for female reproductive disorders
 • 2020  • DOI: 10.1172/jci139681
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Follicular fluid composition and reproductive outcomes of women with polycystic ovary syndrome undergoing in vitro fertilization: A systematic review
 • 2023  • DOI: 10.1007/s11154-023-09819-z
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Interventions to prevent or reduce the incidence and severity of ovarian hyperstimulation syndrome: a systematic umbrella review of the best clinical evidence
 • 2023  • DOI: 10.1186/s12958-023-01113-6
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The prospect of artificial intelligence to personalize assisted reproductive technology
 • 2024  • DOI: 10.1038/s41746-024-01006-x
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The adverse role of endocrine disrupting chemicals in the reproductive system
 • 2023  • DOI: 10.3389/fendo.2023.1324993
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A review of nitric oxide and oxidative stress in typical ovulatory women and in the pathogenesis of ovulatory dysfunction in PCOS
 • 2023  • DOI: 10.1186/s12958-023-01159-6
View Source
Impact of Endocrine Disruptors upon Non-Genetic Inheritance
 • 2022  • DOI: 10.3390/ijms23063350
View Source
Neuroendocrine Determinants of Polycystic Ovary Syndrome
 • 2022  • DOI: 10.3390/ijerph19053089
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Reproductive axis ageing and fertility in men
 • 2022  • DOI: 10.1007/s11154-022-09759-0
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High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models
 • 2022  • DOI: 10.3390/nu14204341
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Male infertility due to testicular disorders
 • 2021  • DOI: 10.1210/clinem/dgaa781
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Endometriosis and polycystic ovary syndrome are diametric disorders
 • 2021  • DOI: 10.1111/eva.13244
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Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms
 • 2021  • DOI: 10.3390/ph14010042
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Metabolic regulation of kisspeptin - the link between energy balance and reproduction
 • 2020  • DOI: 10.1038/s41574-020-0363-7
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Bisphenol A: an emerging threat to female fertility
 • 2020  • DOI: 10.1186/s12958-019-0558-8
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Temperature regulation in women: Effects of the menstrual cycle
 • 2020  • DOI: 10.1080/23328940.2020.1735927
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Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential
 • 2020  • DOI: 10.3390/antiox9100957
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Molecular Mechanisms of Laparoscopic Ovarian Drilling and Its Therapeutic Effects in Polycystic Ovary Syndrome
 • 2020  • DOI: 10.3390/ijms21218147
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Current understanding of hypothalamic amenorrhoea
 • 2020  • DOI: 10.1177/2042018820945854
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Nonsurgical Management of Oligozoospermia
 • 2020  • DOI: 10.1210/clinem/dgaa390
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Molecules and Prostaglandins Related to Embryo Tolerance
 • 2020  • DOI: 10.3389/fimmu.2020.555414
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PACAP: A regulator of mammalian reproductive function
 • 2020  • DOI: 10.1016/j.mce.2020.110912
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The Central Role of Glucokinase in Glucose Homeostasis: A Perspective 50 Years After Demonstrating the Presence of the Enzyme in Islets of Langerhans
 • 2019  • DOI: 10.3389/fphys.2019.00148
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New Insights into the Process of Placentation and the Role of Oxidative Uterine Microenvironment
 • 2019  • DOI: 10.1155/2019/9174521
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Perturbation of Nuclear Hormone Receptors by Endocrine Disrupting Chemicals: Mechanisms and Pathological Consequences of Exposure
 • 2019  • DOI: 10.3390/cells9010013
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Emerging insights into hypothalamic-pituitary-gonadal axis regulation and interaction with stress signalling
 • 2018  • DOI: 10.1111/jne.12590
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KNDy Cells Revisited
 • 2018  • DOI: 10.1210/en.2018-00389
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Steroid Hormones and Their Action in Women's Brains: The Importance of Hormonal Balance
 • 2018  • DOI: 10.3389/fpubh.2018.00141
View Source

60 sources · Platform research library · Not generated by AI

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Research Education Only: This profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions.