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Sexual Health & Hormonal Research High Evidence

PT-141 (Bremelanotide)

Melanocortin receptor agonist (MC4R) studied for sexual dysfunction in both males and females. FDA-approved for HSDD in premenopausal women (Vyleesi).

sexual dysfunctionHSDDmelanocortinarousalFDAbremelanotide
Half-life
~120 minutes
SKUs Available
1
Evidence Level
High Evidence
Mechanism of Action

MC4R agonism in hypothalamus activates sexual arousal pathways. Unlike PDE5 inhibitors, acts centrally on CNS rather than peripherally on vasculature.

Published Research Ranges & Study Context

Studies have administered: 1.25–1.75mg SC in FDA-approved study ranges

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

RECONNECT trials: Statistically significant improvement in satisfying sexual events and desire in HSDD. Female sexual arousal studies show CNS-mediated arousal independent of hormonal status.

High Evidence Multiple large human RCTs available
Side Effects Observed in Research

Nausea (40% in trials), flushing, blood pressure transient increase, hyperpigmentation with repeated use documented

Available Configurations (SKU Reference)
P41
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.