Home › Compound Library › Sexual Health & Hormonal › Kisspeptin-54
Sexual Health & Hormonal Research Moderate Evidence

Kisspeptin-54

Full-length 54 amino acid kisspeptin — the master regulator of the HPG axis. Studied for hypogonadotropic hypogonadism, IVF triggering, and pubertal development. Kisspeptin-10 is the active C-terminal fragment.

kisspeptinHPG axisGnRHLHFSHreproductionIVFhypothalamus
Half-life
~23 minutes vs ~4 minutes for kisspeptin-10; full length provides more sustained signaling
SKUs Available
1
Evidence Level
Moderate Evidence
Mechanism of Action

Full-length kisspeptin-54 is cleaved to kisspeptin-10 in vivo. Binds GPR54 (KISS1R) receptor on GnRH neurons in hypothalamus, triggering pulsatile GnRH release which then drives LH and FSH secretion. Master switch of the reproductive axis. Critical for puberty initiation.

Published Research Ranges & Study Context

Studies have administered: 1–15nmol/kg IV bolus; 0.0–0.5nmol/kg/hr continuous infusion in human LH studies

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Jayasena et al. (2014): IV kisspeptin-54 safely triggers LH surge for IVF — phase 2 success. Reproductive axis activation confirmed in multiple healthy volunteer studies. IVF trigger efficacy comparable to hCG with potentially better safety profile.

Moderate Evidence Phase 1/2 human trials available
Side Effects Observed in Research

Flushing; mild nausea; well-tolerated in multiple human volunteer studies; theoretical OHSS risk (as IVF trigger)

Available Configurations (SKU Reference)
KP54
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

Want a Complete Research Monograph?

Our AI can generate a 2,000+ word deep-dive on Kisspeptin-54 — including full clinical trial summaries, pharmacokinetics, and research frontiers.

Generate Deep Dive in Research Chat
Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.