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Specialty Research Preliminary

Leuphasyl

Pentapeptide enkephalin analogue that acts on opioid receptors in nerve terminals to reduce acetylcholine release at neuromuscular junctions. Studied in combination with argireline for synergistic expression-line reduction.

enkephalinopioid receptorneuromuscularanti-agingtopicalacetylcholinecombination
Half-life
Topical application; penetration studies demonstrate dermal activity
SKUs Available
1
Evidence Level
Preliminary
Mechanism of Action

Tyr-D-Ala-Gly-Phe-Leu sequence mimics met-enkephalin. Binds δ-opioid receptors in nerve terminals, activating G-protein pathway that reduces neurotransmitter vesicle release. Complementary but distinct from SNARE-targeting peptides — acts upstream at neural signaling level.

Published Research Ranges & Study Context

Studies have administered: Topical 5% in research formulations; often combined with argireline

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Combination with argireline (10%) vs argireline alone: greater wrinkle depth reduction. Mechanism synergy via two distinct pathways confirmed in vitro. Clinical trial data shows up to 24% wrinkle reduction in combination protocol.

Preliminary Primarily preclinical + case reports
Side Effects Observed in Research

Well-tolerated topically; opioid receptor activity via topical route unlikely to produce systemic effects at cosmetic concentrations

Available Configurations (SKU Reference)
LEU
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.