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Growth Hormone Axis Research Moderate Evidence

MK-677 (Ibutamoren)

Orally active non-peptide GH secretagogue. Only oral GHS-R1a agonist compound in widespread research. Sustained IGF-1 elevation with once-daily oral dosing makes it uniquely convenient in the GH secretagogue class.

ibutamorenoralGH secretagogueIGF-1ghrelinGHS-R1anon-peptide
Half-life
~4–6 hours; once-daily dosing sufficient due to downstream IGF-1 elevation persistence
SKUs Available
2
Evidence Level
Moderate Evidence
Mechanism of Action

Spiroindoline-based GHS-R1a agonist. Oral bioavailability ~60–70%. Binds ghrelin receptor with long residence time — produces sustained rather than pulsatile GH release. Increases GH pulse amplitude and frequency. Elevates IGF-1 within 2 weeks; sustained with continued use.

Published Research Ranges & Study Context

Studies have administered: 10–25mg/day oral in research; 25mg used in most published trials

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Thorner et al. (1997): first human dose-ranging study confirming sustained IGF-1 elevation. Elderly: improved bone density and body composition. Sleep architecture improvements (SWS increase) documented. Skin thickness improvements in aging subjects. Merck-sponsored trials completed.

Moderate Evidence Phase 1/2 human trials available
Side Effects Observed in Research

Increased appetite (significant — ghrelin mechanism); water retention; potential blood glucose elevation; lethargy/sedation; joint discomfort from IGF-1 elevation; potential tumor promotion concern in active cancer

Available Configurations (SKU Reference)
MK25 MK50
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.