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Cognitive & Mood Research Moderate Evidence

NA-1 (Nerinetide)

PSD-95 inhibitor peptide studied for acute ischemic stroke neuroprotection. Designed to prevent excitotoxic neuronal death post-stroke. Phase 3 ESCAPE-NA1 trial completed with notable subgroup findings.

PSD-95strokeneuroprotectionexcitotoxicityNMDAischemianerinetide
Half-life
~4 hours IV; designed for single acute administration in stroke setting
SKUs Available
1
Evidence Level
Moderate Evidence
Mechanism of Action

Cell-permeable peptide that disrupts PSD-95 scaffolding protein interactions with NMDA receptor and nNOS enzyme. Prevents the PSD-95-mediated coupling of NMDA excitotoxicity to nitric oxide synthase activation and subsequent neuronal death post-ischemia. Reduces infarct volume without affecting NMDA receptor function directly.

Published Research Ranges & Study Context

Studies have administered: 2.6mg/kg IV single dose in phase 3 trial (ESCAPE-NA1)

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

ESCAPE-NA1 (2020, Lancet): primary endpoint missed (overall). Key finding: subgroup receiving mechanical thrombectomy alone (no tPA) showed significant 59% reduction in poor outcomes — alteplase interaction blunted efficacy. Ongoing analysis, potential for tPA-free patient selection.

Moderate Evidence Phase 1/2 human trials available
Side Effects Observed in Research

Well-tolerated in phase 3; no significant safety signals identified; single acute dose administration

Available Configurations (SKU Reference)
NA110
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.