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Specialty Research Moderate Evidence

Palmitoyl Tripeptide-5

Lipid-conjugated tripeptide that activates TGF-β signaling to stimulate collagen synthesis. Studied alongside Matrixyl (palmitoyl pentapeptide-4) for complementary anti-aging dermatology research. Part of the Matrixyl 3000 combination.

collagenTGF-betaskinanti-agingtopicalfibroblastMatrixyl 3000
Half-life
Topical penetration via palmitate; local dermal activity, minimal systemic exposure
SKUs Available
1
Evidence Level
Moderate Evidence
Mechanism of Action

Pal-KVK sequence activates thrombospondin-1 receptor signaling, triggering TGF-β release and downstream collagen I and IV synthesis. Complementary pathway to Matrixyl's matrikine mechanism. The combination (Matrixyl 3000) uses both peptides for dual collagen stimulation pathway activation.

Published Research Ranges & Study Context

Studies have administered: Topical 2–10ppm in research formulations; clinical concentration in Matrixyl 3000 formulations

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

In vitro: collagen I, III, and IV synthesis increase in fibroblast cultures. Clinical combination (Matrixyl 3000): 35–50% wrinkle depth reduction vs placebo in double-blind trials. Synergistic effect with palmitoyl pentapeptide-4 confirmed.

Moderate Evidence Phase 1/2 human trials available
Side Effects Observed in Research

Excellent topical safety; minimal sensitization risk; no systemic concerns from topical application

Available Configurations (SKU Reference)
PT5
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.