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Tissue Repair & Recovery Research Moderate Evidence

Pentosan Polysulfate (PPS)

Semi-synthetic polysaccharide studied for joint cartilage repair, interstitial cystitis, and osteoarthritis. Approved drug (Elmiron) for IC. Joint injection studies show cartilage regeneration signals.

cartilagejointosteoarthritisICinterstitial cystitisglycosaminoglycanrepair
Half-life
~4–6 hours; typically dosed 3x daily orally or via joint injection
SKUs Available
1
Evidence Level
Moderate Evidence
Mechanism of Action

Stimulates synoviocyte production of lubricin and hyaluronic acid. Inhibits cartilage-degrading enzymes (aggrecanase, MMP-3). Anti-inflammatory in synovial tissue. Mild anticoagulant effects (structural similarity to heparin). Bladder glycosaminoglycan layer restoration in IC.

Published Research Ranges & Study Context

Studies have administered: 100mg three times daily oral (approved IC dose); 1–3mg/kg IA injection in joint research

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

FDA-approved for interstitial cystitis (oral). Joint injection phase 2: cartilage protection and symptom reduction in OA. Equine veterinary research extensive. Human OA trials ongoing in Australia.

Moderate Evidence Phase 1/2 human trials available
Side Effects Observed in Research

Pigmentary maculopathy risk with long-term high-dose oral use (important monitoring consideration); anticoagulant effects at high dose

Available Configurations (SKU Reference)
PPS100
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.