Scientific Glossary

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Senescent cells stop dividing but remain metabolically active, secreting a complex mixture of inflammatory cytokines, chemokines, and proteases called the SASI (Senescence-Associated Secretory Phenotype). Over time, senescent cell accumulation is believed to drive tissue dysfunction and inflammaging. Senolytics (compounds that selectively eliminate senescent cells) are an active research area in longevity science. GHK-Cu and epithalon have been studied in the context of senescence modulation.