Scientific Glossary

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Inflammaging (portmanteau of inflammation + aging) describes the chronic, sterile, low-grade inflammatory state that characterizes aging. Driven by senescent cells (SASP), mitochondrial dysfunction, gut dysbiosis, and accumulated cellular damage. Associated with increased IL-6, TNF-α, CRP, and other inflammatory markers. Most age-related diseases (cardiovascular, metabolic, neurological, cancer) share inflammaging as a common driver. Anti-inflammatory peptides studied for longevity include KPV, ARA-290, and thymosin alpha-1.