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Body Composition Research Preliminary

ACE-031 (Ramatercept)

Soluble activin receptor type IIB (ActRIIB) fusion protein — potent myostatin pathway inhibitor. Studied for Duchenne muscular dystrophy and muscle wasting. Dramatically increases lean mass in human trials before safety pause.

myostatinActRIIBmusclelean massDuchenneactivinbody composition
Half-life
~14 days; monthly dosing in trials
SKUs Available
1
Evidence Level
Preliminary
Mechanism of Action

ActRIIB-Fc fusion protein acts as decoy receptor, sequestering myostatin, activin A, GDF-11, and other TGF-β superfamily members that limit muscle growth. Removes the "brake" on muscle fiber hypertrophy. Greatest lean mass increases seen in any single compound in clinical research history.

Published Research Ranges & Study Context

Studies have administered: 1–3mg/kg monthly SC in phase 2 studies; dramatic lean mass gains at low doses

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Phase 2 (Acceleron/Shire): 3mg/kg produced ~1.5kg lean mass in 28 days — extraordinary rate. Trial paused due to bleeding, telangiectasia, and gum bleeding (vascular effects of activin/TGF-β pathway modulation). Muscle efficacy unprecedented.

Preliminary Primarily preclinical + case reports
Side Effects Observed in Research

Vascular adverse events drove trial pause: epistaxis, gum bleeding, telangiectasia; likely due to activin/TGF-β pathway roles beyond muscle

Available Configurations (SKU Reference)
ACE031
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.