Home › Compound Library › Body Composition › Follistatin-344
Body Composition Research Emerging

Follistatin-344

Endogenous myostatin and activin antagonist. Studied for muscle hypertrophy, fertility, and metabolic effects. Significantly increases lean body mass in animal models. Limited human pharmacokinetic data.

myostatinfollistatinmusclehypertrophyactivinTGF-betabody composition
Half-life
Not well-characterized for exogenous administration; endogenous forms have local tissue activity
SKUs Available
1
Evidence Level
Emerging
Mechanism of Action

Secreted glycoprotein that binds and neutralizes myostatin (GDF-8), activin A and B, and BMP-2/4. Multiple binding sites with very high affinity neutralize multiple TGF-β superfamily inhibitors of muscle growth simultaneously. The 344 isoform has distinct heparin-binding characteristics vs 288 isoform.

Published Research Ranges & Study Context

Studies have administered: Research phase only; gene therapy vectors more studied; injectable pharmacology limited data

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Animal models: 200–300% muscle mass increase with gene therapy expression. Exogenous protein: meaningful but more modest effects. Human gene therapy trial (Lee, 2014): increased muscle mass in muscular dystrophy patients. Direct peptide injection human data sparse.

Emerging Early-stage research — limited human data
Side Effects Observed in Research

Limited human pharmacokinetic safety profile available; theoretical concern of off-target activin/BMP pathway modulation in non-muscle tissues

Available Configurations (SKU Reference)
FST344
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

Want a Complete Research Monograph?

Our AI can generate a 2,000+ word deep-dive on Follistatin-344 — including full clinical trial summaries, pharmacokinetics, and research frontiers.

Generate Deep Dive in Research Chat
Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.