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Body Composition Research Preliminary

Amlexanox

Approved aphthous ulcer treatment (Aphthasol) being repurposed as metabolic compound. Inhibits TBK1 and IKKε kinases, reversing metabolic effects of obesity-induced inflammation. Studied for weight loss, insulin sensitivity, and NASH.

TBK1IKKεmetabolisminsulin resistanceobesityinflammationNASH
Half-life
~7.5 hours oral; twice-daily dosing in studies
SKUs Available
1
Evidence Level
Preliminary
Mechanism of Action

Selective inhibitor of Tank Binding Kinase 1 (TBK1) and IκB kinase ε (IKKε) — kinases activated in obesity that impair insulin signaling and increase energy expenditure suppression. By inhibiting these, amlexanox restores normal energy expenditure and insulin sensitivity in obese metabolic states.

Published Research Ranges & Study Context

Studies have administered: 25–100mg twice daily oral in metabolic research studies

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Reilly et al. (2013) Nature Medicine: reduced body weight and adiposity in obese mice. Human phase 2 (Saltiel group): a subset of obese subjects with metabolic inflammation showed significant weight loss and improved insulin sensitivity. Biomarker-selected responder analysis key finding.

Preliminary Primarily preclinical + case reports
Side Effects Observed in Research

Diarrhea, nausea; elevated transaminases in some subjects; mouth ulcers at topical doses; well-characterized safety from aphthous ulcer indication

Available Configurations (SKU Reference)
AMX50
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.