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Sexual Health & Hormonal Research High Evidence

Bremelanotide (PT-141 injectable)

Cyclic melanocortin peptide (same active compound as PT-141 but characterized in injectable research context). FDA-approved as Vyleesi for HSDD in premenopausal women. Studies in male sexual dysfunction ongoing.

bremelanotideMC4Rsexual arousalHSDDVyleesifemale sexual dysfunctionCNS
Half-life
~2.7 hours; on-demand dosing 45 minutes before activity
SKUs Available
1
Evidence Level
High Evidence
Mechanism of Action

MC3R and MC4R agonist in brain reward and hypothalamic circuits modulating sexual arousal. Unlike PDE5 inhibitors, acts on central CNS motivation pathway rather than peripheral vasodilation. Does not require sexual stimulation to work. Dopaminergic and oxytocinergic pathways activated secondarily.

Published Research Ranges & Study Context

Studies have administered: 1.75mg SC on-demand (approved female HSDD dose); 2mg studied in males

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Approved (2019) as Vyleesi for HSDD. Phase 3: significantly improved FSFI desire domain vs placebo. Male studies: improved erectile function in men who failed PDE5 inhibitors. Mechanism distinct from all approved alternatives.

High Evidence Multiple large human RCTs available
Side Effects Observed in Research

Nausea (most common, ~40%); flushing; hyperpigmentation with repeated use; transient blood pressure changes; headache

Available Configurations (SKU Reference)
BREM2
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.