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Growth Hormone Axis Research Moderate Evidence

CJC-1295 (No DAC)

GHRH analogue without the Drug Affinity Complex (DAC) modification. Functionally identical to Modified GRF(1-29). Short-acting GHRH analogue favored by researchers who prefer pulsatile GH release over the sustained "GH bleed" of the DAC version.

CJC-1295no-DACGHRHpulsatilesecretagogueGH releaseshort-acting
Half-life
~15–30 minutes; same as Mod-GRF(1-29)
SKUs Available
1
Evidence Level
Moderate Evidence
Mechanism of Action

GHRH receptor agonist identical in mechanism to Mod-GRF(1-29). Lacks cysteine-maleimide conjugation that enables DAC albumin binding. Half-life governed by DPP-IV resistance from substituted amino acids alone (~15–30 min). Produces clean, pulsatile GH release closely mimicking endogenous patterns.

Published Research Ranges & Study Context

Studies have administered: 100–200mcg per injection, typically combined with GHRP; 2–3x daily dosing

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Robust pulsatile GH release verified. Synergy with ipamorelin and GHRP class well-documented. Preferred over DAC variant for sleep-time GH pulse research (mimics physiological nocturnal GH surge).

Moderate Evidence Phase 1/2 human trials available
Side Effects Observed in Research

Flushing (transient); injection site reactions; water retention with continued use; minimal cortisol/prolactin elevation (unlike GHRPs)

Available Configurations (SKU Reference)
CJC-ND2
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.