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Growth Hormone Axis Research Moderate Evidence

Modified GRF(1-29)

Stabilized 29-amino acid GHRH analogue without the DAC modification of CJC-1295. Shorter acting than CJC-1295-DAC — produces physiological-style GH pulses. Often combined with GHRP-2 or ipamorelin for synergistic GH release.

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Half-life
~15–30 minutes; short enough for pulsatile physiological GH mimicry
SKUs Available
1
Evidence Level
Moderate Evidence
Mechanism of Action

Growth hormone-releasing hormone (GHRH) analogue — binds GHRH receptor on pituitary somatotrophs, stimulating GH pulse. Four amino acid substitutions vs native GHRH prevent DPP-IV degradation, extending half-life from 2 minutes to ~15–30 minutes. No albumin binding (distinguishing it from DAC version).

Published Research Ranges & Study Context

Studies have administered: 100mcg per injection, 2–3 injections daily in combination protocols

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Potent GH pulse stimulation confirmed. Combination with ipamorelin or GHRP-2: synergistic GH amplitude increase 4–10x vs either alone. Physiological pulsatility preserved. More natural GH release pattern vs CJC-1295-DAC.

Moderate Evidence Phase 1/2 human trials available
Side Effects Observed in Research

Injection site reactions; flushing sensation immediately post-injection; water retention; generally considered cleaner side effect profile than DAC version due to pulsatile nature

Available Configurations (SKU Reference)
MGF2
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.