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Sexual Health & Hormonal Research High Evidence

Melanotan-I (afamelanotide)

Linear melanocortin MC1R agonist (parent to MT-II). FDA-approved (Scenesse) for erythropoietic protoporphyria (EPP). Studied for photoprotection, tanning, and skin disorder research. Lacks the sexual side effects of MT-II.

melanocortinMC1RtanningphotoprotectionEPPScenesseafamelanotide
Half-life
~90 minutes SC; implant (Scenesse) provides sustained release for 60 days
SKUs Available
1
Evidence Level
High Evidence
Mechanism of Action

Selective MC1R agonist — activates melanocyte-stimulating hormone receptor in melanocytes, stimulating eumelanin production and skin darkening. No significant MC3R/MC4R activity (distinguishing from MT-II which causes sexual arousal via MC4R). Approved SCENESSE implant releases sustained dose.

Published Research Ranges & Study Context

Studies have administered: 16mg subcutaneous implant for EPP (approved); 0.16mg/day equivalent; research doses lower

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

FDA approved Scenesse (afamelanotide) for EPP in 2019. Proven photoprotection in EPP patients. Vitiligo repigmentation studies positive. Clinical research ongoing for polymorphous light eruption, solar urticaria.

High Evidence Multiple large human RCTs available
Side Effects Observed in Research

Nausea, flushing, yawning; darker/new nevi (require monitoring); no sexual arousal effects (MC4R-sparing distinguishes from MT-II)

Available Configurations (SKU Reference)
MT1-10
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.