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Cognitive & Mood Research Preliminary

Noopept (GVS-111)

Proline-containing dipeptide nootropic studied for cognitive enhancement, neuroprotection, and anxiety reduction. Developed in Russia. Rapidly crosses BBB; active at nanogram doses. Different mechanism from racetam class.

nootropiccognitiveAMPANGFBDNFneuroprotectionRussiaGVS-111
Half-life
Very short plasma half-life (~5 minutes); CNS activity much longer due to cycloprolylglycine conversion
SKUs Available
1
Evidence Level
Preliminary
Mechanism of Action

Hydrolyzed in brain to release cycloprolylglycine — endogenous neuropeptide ligand for AMPAkine sites. Also increases BDNF and NGF expression in brain. Modulates AMPA and NMDA receptor signaling. Anxiolytic effects via possible GABA-A potentiation. Alpha wave enhancement observed in EEG studies.

Published Research Ranges & Study Context

Studies have administered: 10–30mg/day oral or intranasal in Russian clinical research; intranasal may provide better CNS delivery

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Ostrovskaya (2009): cognitive improvement in mild cognitive impairment subjects. Neuroprotection against excitotoxicity in multiple models. EEG: alpha and beta power increases. Russian regulatory approval for cognitive dysfunction treatment (different standard than FDA).

Preliminary Primarily preclinical + case reports
Side Effects Observed in Research

Generally well-tolerated; headache, irritability at high doses; Russian RCT data suggests good safety; regulatory status varies by country

Available Configurations (SKU Reference)
NP10
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.