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Longevity & Mitochondrial Research Preliminary

Spermidine

Naturally occurring polyamine found in aged cheese, wheat germ, and mushrooms. Studied as an autophagy inducer with potential for cardiovascular protection, neuroprotection, and lifespan extension. Declines naturally with age.

autophagypolyaminelongevitycardiovascularcognitionagingnatural
Half-life
~1.5 hours plasma; cellular spermidine pools maintained longer
SKUs Available
1
Evidence Level
Preliminary
Mechanism of Action

Autophagy induction via inhibition of EP300 acetyltransferase, leading to Atg protein deacetylation and autophagosome formation. Hypusination of eIF5A translation factor. Anti-inflammatory via reducing IL-6, IL-1β production. Stabilizes DNA repair complexes.

Published Research Ranges & Study Context

Studies have administered: 1.2–3.4mg/day from dietary sources or supplements in observational studies; 1.2mg/day in intervention trials

Important Research Framing These are ranges reported in published scientific studies. They are provided for educational context only and do not constitute dosing recommendations. Individual study parameters vary by design, population, and research objectives. This information is not medical advice.
Primary Research Findings

Eisenberg et al. (2016): dietary spermidine correlated with reduced cardiovascular mortality in 45,000-person cohort. Human trials show improved cognitive performance in older adults. Pilot human trial: improved cognitive function (Austrian group, 2021).

Preliminary Primarily preclinical + case reports
Side Effects Observed in Research

Generally well-tolerated; GI discomfort at high doses; naturally present in many foods

Available Configurations (SKU Reference)
SPD1
Compounds Studied in Combination

These compounds have been examined together in research literature. Combination use is not endorsed or recommended — this information is provided for research context only.

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Research Education Only: This compound profile is for educational purposes only. All information is sourced from published scientific literature. This is not medical advice. Not for human consumption. Consult qualified medical professionals for any health decisions. Regulatory status varies by jurisdiction.